Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Trial status:Recruiting
Study Identifier:
BNT327-01
ClinicalTrials.gov Identifier:
NCT06449209
EudraCT Identifier:
N/A
Sponsor:
The sponsor of a clinical trial is the company, institution or individual that takes responsibility for initiating, managing, and/or financing a clinical investigation. BioNTech collaborates with other pharmaceutical companies or institutions (collaborators) to develop certain new medicines. In particular cases BioNTech's collaborators are leading specific clinical trials and are acting as sponsors accordingly.
BioNTech SE
Recruiting

Trial details

Medical Condition
  • Lung Cancer
    • Study Drug
  • Drug: BNT327 Dose Level 1 (DL1)
  • Drug: BNT327 Dose Level 2 (DL2)
  • Drug: Topoisomerase Inhibitor A
    • See more
  • Drug: Alkylating agent
  • Drug: Taxane
  • Drug: Topoisomerase Inhibitor B
    • Phase
    Phase 2
    Sex
    Female & Male
    Age
    18+
    Estimated Trial Date
    Aug 2024 - Jan 2025

    Protocol summary

    This is a Phase II, multi-site, open-label, parallel group study in participants with untreated extended-stage small-cell lung cancer (ES-SCLC) (Cohort 1) or small-cell lung cancer (SCLC) progressed on first- or second-line treatment (Cohort 2 and Cohort 3).

    Trial locations

    Location
    Status
    Location
    Valkyrie Clinical Trials
    Los Angeles, California, United States, 90067
    Status
    Recruiting
    Location
    Clermont Oncology Center
    Clermont, Florida, United States, 34711
    Status
    Recruiting
    Location
    Fort Wayne Medical Oncology and Hematology, Inc
    Fort Wayne, Indiana, United States, 46804
    Status
    Recruiting
    Location
    Clinical Research Alliance Inc
    Westbury, New York, United States, 11590
    Status
    Recruiting
    Location
    University of Tennessee Medical Center
    Knoxville, Tennessee, United States, 37920
    Status
    Not yet recruiting
    Location
    North Devon District Hospital - Northern Devon Healthcare NHS Trust
    Barnstaple, United Kingdom, ES31 4JB
    Status
    Not yet recruiting