ROSETTA Breast‑01: The Effects and Safety of Pumitamig in Patients With Triple‑Negative Breast Cancer

Trial status:Will Be Recruiting
Trial ID:
BNT327-05
NCT ID:
NCT07173751
EudraCT ID:
N/A
EU Trial (CTIS) Number:
2025-521884-12-00
Sponsor:
The sponsor of a clinical trial is the company, institution or individual that takes responsibility for initiating, managing, and/or financing a clinical investigation. BioNTech collaborates with other pharmaceutical companies or institutions (collaborators) to develop certain new medicines. In particular cases BioNTech's collaborators are leading specific clinical trials and are acting as sponsors accordingly.
BioNTech SE
Will Be Recruiting

Trial Details

This is a Phase III trial where participants will be randomized to two treatment groups, which means participants will be assigned by equal chance to a treatment group. This trial will be double-blinded, which means neither the participants nor the trial doctors will know which of the two treatments the participants actually receive. Participants will receive either the trial drug with chemotherapy or placebo (which looks like the trial drug but does not have any drug in it) with chemotherapy.

Medical Condition
  • Unmapped
    • Trial Drug
  • Pumitamig
    • See more
  • Nab-paclitaxel/Paclitaxel
  • Gemcitabine
  • Carboplatin
  • Eribulin
  • Matching placebo
    • Phase
    Phase 3
    Type
    Interventional
    Estimated Enrolment
    558
    Estimated Trial Date
    Oct 2025 - Dec 2029

    Trial Participant Requirements

    Age
    18+ years
    Sex
    Female & Male
    Healthy Volunteers
    No
    Inclusion and Exclusion Criteria
    Inclusion criteria

      Inclusion Criteria:

    • Are considered ineligible for combination treatment with a monospecific PD(L)1 targeting immunotherapy plus chemotherapy as per their tumor PD-L1 expression status.
    • Have confirmed locally recurrent inoperable or metastatic TNBC, or estrogen receptor (ER)-low, human epidermal growth factor receptor 2 (HER2)-negative breast cancer (ER and/or progesterone receptor [PgR]) 1% to 10%, HER2 immunohistochemistry [IHC] 0, 1+, or 2+ with fluorescence in situ hybridization [FISH] negative for HER2 gene amplification) documented prior to trial screening as part of standard of care.
    • Have at least one measurable lesion as the targeted lesion based on RECIST v1.1.
    • Have provided a tissue sample, archival or fresh, during the screening period (bone biopsies, fine needle aspiration biopsies, and samples from pleural or peritoneal fluid are not acceptable; participants with only one target lesion are not eligible to participate in the trial).
    • Eastern cooperative oncology group (ECOG) performance status of 0 or 1.

      • Exclusion Criteria:

    • Have received any of the following therapies or drugs prior to the initiation of trial:
      • Have received prior systemic anticancer therapy for advanced disease.
      • Have received prior treatment with a PD(L)-1/vascular endothelial growth factor (VEGF) bispecific antibody.
      • Have received systemic corticosteroids (at a dosage greater than 10 milligrams [mg]/day of prednisone or an equivalent dose of other corticosteroids) within 7 days prior to the initiation of trial treatment. Exception: excluding local, intranasal, intraocular, intra-articular or inhaled corticosteroids, short-term use (\<= 7 days) of corticosteroids for prophylaxis (for example, prevention of contrast agent allergy) or treatment of non-autoimmune conditions (for example, delayed hypersensitivity reactions caused by exposure to allergens).
      • Have been vaccinated with live attenuated vaccine(s) within 4 weeks prior to initiation of trial treatment.
      • Have received broad-spectrum intravenous antibiotics therapy within 2 weeks prior to initiation of trial treatment.
    • Are pregnant or breastfeeding or are planning pregnancy or planning to father children during the trial or within 6 months after the last dose of pumitamig or placebo.
    • Have undergone major organ surgery, significant trauma, or invasive dental procedures (such as dental implants) within 28 days prior to the initiation of trial treatment or plan to undergo elective surgery during the trial. Placement of vascular infusion devices is allowed.
    • Have received allogeneic hematopoietic stem cell transplantation or organ transplantation.

    Trial Locations

    No locations found.